高效液相色谱法测定尼可刹米注射液的含量
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[摘要] 目的 建立用高效液相色谱法测定尼可刹米注射液含量的方法。方法 选用Eclipse DCB-C18色谱柱(150 mm×4.6 mm，5μm)；以乙腈-水(20∶80)为流动相；流速1.0 mL/min，检测波长263 nm。结果 尼可刹米在0.549～10.980 mg/mL范围内呈良好的线性关系(r=0.9993)，平均加样回收率为100.6%(RSD=1.2%，n=6)。结论 本方法准确、重复性好，可用作尼可刹米注射液的质量控制。
[关键词] 尼可刹米注射液；高效液相色谱；含量测定
[中图分类号] R927.2 [文献标识码] A [文章编号] 2095-0616(2011)21-87-02
Determination the content of Nikethamide injection by HPLC
JIANG Fengwei
Jiaozuo Institute for Food and Drug Control in Henan Province, Jiaozuo 454000,China
[Abstract] Objective To establish a method for determination the content of Nikethamide injection by HPLC. Methods The Eclipse DCB-C18 column(150 mm×4.6 mm,5μm) was used. The mobile phase was acetonitrile-water(20∶80). The flow rate was 1.0 mL/min and the detection wavelength was 263 nm.Results The linear range of Nikethamide was 0.549~10.980 mg/mL(r=0.9993) ......
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